ABSTRACT
Objective: The objective of the present work was to formulate and evaluate a stable, odour free garlic powder loaded floating matrix tablet for the treatment of peptic ulcers. Methods: A gastro-retentive floating matrix tablet (FMT) formulation of garlic powder (GP) was prepared using various concentrations of hydroxypropyl methylcellulose K4M (HPMC K4 M) and effervescent system (sodium bicarbonate and citric acid in 1:1 % w/w) to achieve desirable floating time (FT), floating lag time (FLT) and drug release. Wet granulation method was selected using ethanol as a binder for preparation of tablet. 32 full factorial designs were used for selection of suitable polymer concentration and effervescent system. Nonenteric film coating was applied to mask GP odour. Results: It was observed that FMT with optimum quantities of HPMC K4M and the effervescent system showed 97 % of drug release in 12 h with FT up to 10 h and minimum FLT of 3 min. There was no significant change in FLT, FT and drug content during the stability study of FMT. Conclusion: A stable, sustained release FMT of GP tablets using HPMC K4M and an effervescent system was successfully prepared. This formulation can overcome problems of taste and odour masking, gastric irritation, and loss of active constituents present in garlic.
ABSTRACT
Objective: The objective of the present work was to formulate and evaluate a stable, odour free garlic powder loaded floating matrix tablet for the treatment of peptic ulcers. Methods: A gastro-retentive floating matrix tablet (FMT) formulation of garlic powder (GP) was prepared using various concentrations of hydroxypropyl methylcellulose K4M (HPMC K4 M) and effervescent system (sodium bicarbonate and citric acid in 1:1 % w/w) to achieve desirable floating time (FT), floating lag time (FLT) and drug release. Wet granulation method was selected using ethanol as a binder for preparation of tablet. 32 full factorial designs were used for selection of suitable polymer concentration and effervescent system. Nonenteric film coating was applied to mask GP odour. Results: It was observed that FMT with optimum quantities of HPMC K4M and the effervescent system showed 97 % of drug release in 12 h with FT up to 10 h and minimum FLT of 3 min. There was no significant change in FLT, FT and drug content during the stability study of FMT. Conclusion: A stable, sustained release FMT of GP tablets using HPMC K4M and an effervescent system was successfully prepared. This formulation can overcome problems of taste and odour masking, gastric irritation, and loss of active constituents present in garlic.
ABSTRACT
The objective of present study was to develop controlled release floating matrix tablets of Acyclovir using combination of release retarding polymers: hydroxypropyl methylcellulose (HPMC K15M CR) and polyethylene oxide (Polyox WSR 303) for treatment of herpes infections using direct compression technique. The influence of type of polymer and its concentration on the drug release from prepared floating tablets was investigated using a 32 factorial design. Independent variables selected were concentration of Polyox WSR 303 (X1) and HPMC K15M CR (X2) while dependent variables were percentage cumulative drug release at 3, 9 and 12 h (Q3, Q9, and Q12). Analysis of variance (ANOVA) and multiple regression analysis showed significant effect on Q3, Q9, and Q12. Formulations also contained sodium bicarbonate (NaHCO3) and anhydrous citric acid as floating agent, polyvinyl pyrrolidone (PVP K30) as dry binder and microcrystalline cellulose (MCC, Avicel PH 102) as diluent. The floating tablets were evaluated for their floating lag time (FLT), floating duration, hardness, friability, weight variation, and in-vitro drug release, dissolution efficiency and accelerated stability study. F2 with Polyox WSR 303 (50 mg) and HPMC K15M CR (15 mg) gave best results. Stability study revealed optimized formulation F2 to remain stable. A controlled release floating matrix tablet of Acyclovir was successfully prepared by using Polyox WSR 303 and HPMC K15M CR.